Herpes at the corners of the mouth may be caused by keratitis, herpes orofacialis, contact labyrinthitis and other diseases, which need to be treated with medication and other treatments for the cause of the disease. 1. Keratitis: common symptoms are redness of the corners of the mouth, blistering, flaking and so on. If it is caused by bacterial infection, patients need to follow the doctor’s instructions for local topical antibiotic drugs such as compound gentamicin hydrochloride ointment and erythromycin ointment. If it is caused by fungal infection, patients need to follow the doctor’s instructions to apply clotrimazole cream, miconazole cream and other antifungal drugs. For long-term recurring keratitis, patients need to consider weak laser treatment, is a common auxiliary treatment measures, to a certain extent, can also play the role of anti-inflammatory, sterilization. 2. Oral and lip herpes: mainly manifested in the corners of the mouth or lip edges of the dense groups of blisters. Patients need to follow the doctor’s instructions to use 3% acyclovir ointment, 1% penciclovir ointment and other antiviral drugs. If the symptoms are severe, oral antiviral drugs such as valaciclovir and ganciclovir should be taken as prescribed by the doctor. 3. Contact Lipitis: The corners of the mouth will be swollen, blistered and cracked. Usually, patients need to avoid contact with irritants and use topical glucocorticoid preparations, such as Denuded cream, under the guidance of a doctor. Antihistamines such as loratadine are taken orally if necessary. There are many causes of herpes at the corners of the mouth, and it is necessary to visit the hospital and actively treat the primary disease.