Toothache due to precursor of heart attack is cardiogenic toothache, which is involving in nature, paroxysmal, periodic and insensitive to hot and cold stimuli. When the public is difficult to recognize, it is recommended to seek medical treatment without delay. Cardiogenic dental pain is due to ischemia and hypoxia of the coronary arteries of the heart, too much metabolic substances can not be excreted to stimulate the coronary artery nerves of the heart, and transmitted to the cerebral cortex, impulse conduction process appears “dislocation phenomenon”, and ultimately the patient feels toothache. It is an atypical manifestation of heart attack and is easily overlooked. Cardiogenic dental pain is common in elderly patients, and the pain is mainly episodic or paroxysmal acute pain. Unlike odontogenic pain, cardiogenic pain is not sensitive to hot and cold stimuli, and the pain is cyclical. In most cases, cardiogenic dental pain is associated with mild organic lesions of the dentition. It has been reported in the foreign literature that about 18% of patients with coronary artery stenosis have pain manifesting in the jaws and teeth, similar to the symptoms of toothache due to acute pulpitis. The obvious toothache and delayed cardiovascular symptoms cause false impression and interference to the stomatologist, which may lead to misdiagnosis. Therefore, it is important to be aware of the cardiac causes of toothache. Elderly patients in particular should pay close attention to the symptoms and seek medical attention without delay, so as not to miss the best time for treatment.