Irbesartan and nifedipine can be taken at the same time. The former is an angiotensin‖ receptor antagonist; the latter is a calcium channel blocker, and the combined application of the two drugs can produce a synergistic effect, which can lower blood pressure more effectively. 1. Irbesartan is an angiotensin II receptor antagonist, which is used for various kinds of primary hypertension, after acute myocardial infarction, heart failure, etc. It is often used in combination with calcium channel blockers. The common adverse reactions of Irbesartan are headache, palpitations, etc. Occasionally cough, rare occurrence of urticaria, angioneurotic edema and upright hypotension. It is contraindicated for those who are allergic to this product. During the period of taking the medicine, pay attention to light diet and regular life. 2. Nifedipine tablets are calcium channel blockers, which can be used for hypertension, angina pectoris, variant angina pectoris, chronic stable angina pectoris and so on. The adverse reactions of nifedipine are dizziness, weakness, dry mouth, palpitations, etc. Prolonged use can lead to lower limb edema, which can be avoided by combining with diuretics. Severe aortic stenosis, unstable angina, severe aortic valve stenosis, hypertrophic obstructive cardiomyopathy, etc., as well as those who are allergic to it are prohibited from taking it. Avoid smoking, alcohol, greasy food, and pay attention to the regularity of life during the period of taking the drug. If you need to take medication, please follow the doctor’s instructions after professional diagnosis and prescription, do not buy and take without authorization, so as to avoid delaying the condition or causing adverse effects on the body.