Stubborn blackheads are a kind of open pimples, which can be removed by general treatment, medication and peeling. 1. General treatment: maintain good living habits, do not stay up late, ensure adequate sleep, avoid mental tension, anxiety, etc.. Do a good job of daily skin cleaning, oil control and moisturizing work. 2. Medication: You can apply topical retinoic acid drugs for treatment, such as retinoic acid cream, isotretinoin gel, etc., which can effectively eliminate stubborn blackheads. 3. Fruit acid peeling: make the keratinocytes of the epidermis to different degrees of shedding, accelerate the metabolism of the stratum corneum as well as the renewal of epidermal cells, to achieve the purpose of treating and repairing blackheads on the skin. These medications above can have different degrees of adverse reactions during treatment, such as burning sensation of the skin, keratinization of the skin, photosensitivity reactions, gastrointestinal irritation, etc., which need to be used under the guidance of a doctor when using them.