Cold hands and feet and sweaty palms in winter may be caused by kidney qi deficiency, kidney yang deficiency, qi and blood deficiency, spleen yang deficiency, etc. Patients can follow the doctor’s instructions to take medication, as well as general measures to regulate. 1. Kidney qi deficiency, kidney yang deficiency: patients may have self-sweating (involuntary sweating during the day, aggravated by sweating with slight movement), lack of warmth in the limbs and other manifestations. Under the guidance of the doctor, the patient can use Jinliao Gujin Pills and Huangqi San to tonify kidney qi, or Right Angelica Pills and Jin Gui Kidney Qi Pills to warm and tonify kidney yang. In addition, it can also be treated with acupuncture and moxibustion at the Ren Yu and Qi Hai points by professional physicians. 2. Qi and blood insufficiency: Patients with Qi and blood insufficiency will have symptoms such as coldness (fear of cold, cold limbs) and spontaneous sweating. It is suggested that patients can use medicines that warm qi and blood such as Shiquan Dachan Pill and Ginseng Nourishing Rong Pill under the guidance of a doctor. Acupuncture and moxibustion can also be used to relieve the symptoms under the guidance of a professional physician, such as Baihui point and Guanyuan point. 3. Spleen-Yang deficiency: patients will have cold limbs, cold sweating and other manifestations. You can follow the doctor’s advice to use Sijunzi Combination, Sijunzi Pill and other Chinese medicines to strengthen the spleen. It can be treated by professional physicians with acupuncture at the mid-epigastric point and spleen point. Patients should pay attention to keeping warm and resting; they should avoid being in a cold environment for a long time, and they should keep their mood relaxed and avoid thinking too much. When patients have cold hands and feet and sweaty palms in winter, it is recommended to consult a doctor in time, and the doctor will choose appropriate measures to treat the cause of the disease. It is not advisable to self-medicate to avoid adverse consequences.