Oxygen therapy is preferred for the treatment of cluster headaches, supplemented by medication. Prevention is mainly through the administration of prophylactic drugs. 1.Treatment: (1) Oxygen therapy: the first choice of treatment for headache attack, giving pure oxygen inhalation for 10~20 minutes can effectively block the headache attack. Oxygen therapy is safe, efficient and has no obvious adverse effects. (2) Drug therapy: Subcutaneous injection of sumatriptan or nasal inhalation, zolmitriptan nasal inhalation can rapidly relieve headache, but it is prohibited for people with cardiovascular and cerebrovascular diseases and hypertension. 2. Prevention: preventive drugs mainly include verapamil, glucocorticoid and lithium preparation. Once diagnosed with cluster headache, preventive treatment should be given immediately to shorten the duration of cluster attacks and reduce the number of attacks. Cluster headache is a type of primary neurovascular headache that can recur in intense, recurrent episodes, affecting daily life. If symptoms occur, it is important to seek immediate medical attention and early treatment to control the attacks.