Insomnia after taking Gui Fu Di Huang Wan may be caused by a mismatch between the drug and the patient’s own illness. Chinese medicine believes that insomnia is insomnia, and its basic pathogenesis is yang-sheng and yin-weakening, yin and yang are out of sync, while Gui Fu Di Huang Wan can warm and tonify the kidney yang, which further aggravates the yang-sheng and yin-weakening, thus leading to insomnia. Insomnia is mostly caused by emotional and emotional injuries, dietary disorders, labor and leisure disorders, and chronic illnesses, etc. The basic pathogenesis of insomnia is yangheng and yin weakening and yin and yang mismatch. There are symptoms such as liver depression that leads to fire (the Qi of the liver is blocked, resulting in the production of fire and heat), phlegm-heat internal disturbance, restlessness of the heart and mind, as well as deficiency of the heart and the spleen (weakness of the heart and the spleen). Gui Fu Di Huang Wan is composed of Radix Rehmanniae Praeparata, Radix Polygoni Multiflori, Radix Cinnamomum Cassiae, Cornus Officinalis, etc. It has the efficacy of warming and tonifying Kidney-Yang (warming and replenishing Kidney-Yang) and is commonly used clinically for treating symptoms of lumbar-knee soreness and tenderness (a feeling of weakness and tenderness of the waist and knees), and frequent urination with cold limbs. It is not suitable for patients with symptoms of dry mouth and tongue, irritability, dry stool and yellow urine. If there are symptoms of insomnia, medical consultation is recommended. Taking Gui Fu Di Huang Wan is recommended to be under the guidance of a doctor.