Pregnant women with high thyroxine have many adverse effects on the fetus, such as leading to fetal growth restriction, malformations, etc. should be treated in a timely manner. High thyroxine in pregnant women can lead to metabolism in pregnant women’s bodies in a relatively active state, endocrine disruption, can have many adverse effects on the growth and development of the fetus, such as leading to fetal growth restriction, fetal malformations, congenital hypothyroidism, goiter, miscarriage, preterm labor, and so on, the serious cases can appear hyperthyroidism crisis, endangering the life of the mother and child, and need to be treated in a timely manner. The principle of treatment for pregnant women with high thyroxine is to control the development of the disease and ensure the normal development of the fetus. Generally, drug treatment is preferred, and the commonly used ones are propylthiouracil and methimazole, but they are not applicable to women in the early stages of pregnancy. In addition, it should be noted that if there is a need for medication, the patient should consult a medical professional to avoid blind use of medication leading to adverse consequences.