The tonsils have been large on one side and small on the other for many years, without other uncomfortable symptoms, usually no treatment is needed. If the tonsils are caused by tonsillitis, medication is needed; if they cause symptoms such as sleep apnea, or if tonsillitis occurs repeatedly, surgical removal is recommended. If the tonsils are large on one side and small on the other, there is no need to take special treatment if there are no other uncomfortable symptoms. Keeping the area clean and dry and avoiding infections is sufficient. When the pathogen infection repeatedly caused tonsillitis, the patient may appear tonsils on one side of the big and small for many years. Patients need to take timely treatment measures, local furacilin solution and other disinfectant gargling, or the application of antibiotic drugs, such as penicillin, cefuroxime, azithromycin and so on. If necessary, tonsil removal surgery is required. Medications must be applied under the direction of a doctor. If the tonsils are large on one side and small on the other, and if they interfere with normal respiratory ventilation and obstructive sleep apnea occurs, surgical removal of the tonsils and opening of the airway is recommended. Patients are advised to visit the hospital to identify the cause. Follow the doctor’s instructions to standardize the treatment.