Appendicitis is a relatively common surgical disease, not particularly serious, and appendectomy is not difficult, yet deaths from acute appendicitis still occur from time to time. How to prevent and minimize the death of appendicitis patients? First of all, timely surgery should be performed to prevent the appendix from becoming septic, perforated or even developing diffuse peritonitis, and some patients may even develop symptoms of toxic shock from infection. The mortality rate of appendicitis is closely related to the patient’s concomitant appendiceal perforation. In addition, it is important to pay attention to the patient’s other important organs for disease, and this group of patients is usually older. Especially in elderly patients, we should pay attention to whether there are other important organ diseases, we should comprehensively analyze and prioritize, pay attention to protect the important organs at the same time appendectomy, to reduce the possibility of death.