The causes of frequent numbness of hands and feet include stroke, metabolic neurotrophic diseases, autoimmune diseases and chronic alcoholic peripheral neuropathy, and the treatment measures mainly include improving the blood circulation of brain tissues, nutritive nerves, controlling blood glucose, immunosuppressive therapy, supplementing vitamin B, and so on. 1. Stroke: patients with cerebral hemorrhage and cerebral infarction commonly suffer from limb numbness and sensory impairment. For patients with cerebral infarction, they need early intravenous infusion of drugs such as alteplase and reteplase to dissolve the thrombus or even interventional thrombolytic surgery to restore the blood supply of brain tissue. Patients with cerebral hemorrhage should control blood pressure, reduce intracranial pressure and have surgery if necessary. 2. Metabolic neurotrophic disease: numbness of limbs is a common symptom of diabetic peripheral neuropathy, patients need to regularly use hypoglycemic drugs or insulin to control blood sugar. 3. Autoimmune diseases: patients with Guillain-Barré syndrome will have numbness in both lower limbs and limbs, patients need to receive cerebrospinal fluid biochemical examination, and receive immunosuppressive treatment such as gammaglobulin infusion and plasma exchange if necessary. 4. Chronic alcoholism peripheral neuropathy: such as Wernicke’s encephalopathy can also lead to numbness of the limbs, patients should be standardized supplementation of vitamin B1 for treatment. It is recommended that patients seek timely medical care to clarify the cause of numbness of the limbs, and receive regular treatment under the guidance of the doctor.