Rheumatoid (or rheumatoid arthritis) is characterized by chronic, aggressive arthritis. The patient’s symptoms are mainly joint manifestations, accompanied by extra-articular manifestations. 1. Joint manifestations: the typical manifestations of patients are symmetrical, polyarticular and peripheral joint inflammation. Both large and small joints can be invaded, but the proximal interphalangeal joints, metacarpophalangeal joints, wrist joints and metatarsophalangeal joints are mainly affected, followed by elbow, knee and hip joints. At the beginning of the disease, it may be a single joint or a wandering multi-joint swelling and pain. The joints are swollen, painful and stiff in the morning, and the stiffness lasts for more than one hour, but it is relieved after activities. As the disease progresses, joint deformation and mobility disorders may occur. 2. Extra-articular manifestations: Rheumatoid arthritis patients may involve multiple organ systems throughout the body. Rheumatoid arthritis causes interstitial pneumonia and pleurisy, which may cause dry cough and fatigue; rheumatoid pericarditis, rheumatoid nodules can be seen on the heart valves of the patients, which are often manifested as chest tightness, angina and other symptoms. Involvement of peripheral nerve fiber lesions can lead to hyperalgesia, muscle weakness and atrophy, wrist and foot ptosis; eye damage is dry keratitis, scleritis symptoms. Some patients often accompanied by fatigue, loss of appetite, weight loss, low fever and other general symptoms. It is recommended that patients go to the rheumatology and immunology department of regular hospitals in time according to their symptoms, and under the guidance of doctors for standardized treatment, so as to avoid delaying the condition and causing serious consequences.