Castleman’s disease has the potential to be cured, but the cure rate is relatively low. Castleman’s disease is an autoimmune disease, also known as giant lymphocyte hyperplasia. It is rare in clinical practice, and the cause of the disease may be related to genetics, infections and other factors. Whether or not Castleman’s disease can be cured depends on the specific type of the disease. It is usually divided into focal and multicentric types. Focal Kastmann’s disease is less likely to recur after surgical removal of localized enlarged lymph nodes, and patients can survive for a long time. Multicentric Castleman’s disease is more difficult to treat and usually requires chemotherapy or even hematopoietic stem cell transplantation. The prognosis is poorer, and it is prone to complications from other diseases, and it may deteriorate to form lymphoma. Patients with Castleman’s disease need to pay attention to rest and avoid excessive mental stress during treatment.