In clinical examination, p16 negative ki67 positive results usually indicate that the body does not have persistent human papillomavirus (HIV) infection, but there is a problem of cell proliferation, and it is recommended to pay attention to it in time. P16 and Ki67 are common clinical tests that are useful for screening cervical lesions. p16 negative results indicate that there is no persistent human papillomavirus (HIV) infection, while Ki67 is a nuclear antigen gene that reflects cell proliferation, and a positive result often indicates that there is a cell proliferation problem in the body. In case of p16 negative ki67 positive test results, it is recommended to consult a doctor in time to clarify the cause of the disease with the help of the doctor, and to carry out targeted treatment or therapy.