Thick and large tongue may be caused by congenital dysplasia, infection, tumor and other factors, and can be treated with medication or surgery. 1. Congenital dysplasia, some patients with congenital dysplasia may lead to a thick tongue, which may affect normal life and symptoms of unclear speech and dysphagia, and may require surgical treatment to correct the symptoms of a thick tongue and remove the hypertrophied part of the tongue. 2. Infection, if infected with bacteria, viruses or other pathogens, may lead to tongue hyperplasia, so there will be a thick tongue speech unclear swallowing difficulty symptoms, you can use medication under the guidance of the doctor, commonly used drugs are amoxicillin, cefixime, etc., if caused by viral infections, you can use acyclovir, vaxilovir, and other drugs to treat. 3. Tumor, patients with tumors may lead to thick tongue need timely surgical treatment, excision of the tumor, if malignant neoplastic disease also need to carry out radiotherapy or targeted drug therapy. If there are obvious discomfort symptoms, it is best to actively seek medical attention.