Pre-meal pain is also characterized by hunger pain, mostly duodenal ulcer, and often manifested as pain at night in the early morning, after eating can make the pain relief, taking acid-suppressing drugs after the pain will also be significantly relieved. For duodenal ulcer is also accompanied by abdominal distension, nausea, acid reflux, belching, indigestion and other symptoms, it is recommended that if the regular appearance of preprandial pain, hunger pain, the need to go to the hospital in a timely manner, with the doctor to improve the electronic gastroscopy to help clarify the specific causes. If there is indeed duodenal ulcer, you need to cooperate with the doctor to give the use of anti-ulcer drug therapy, generally use acid inhibitors combined with gastric mucosal protection agents, such as oral omeprazole or lansoprazole proton pump inhibitors combined with bismuth treatment. If there is Helicobacter pylori infection, you need to give the regular four-phase therapy to eradicate Helicobacter pylori treatment, in order to promote the healing of the ulcer to prevent the recurrence of ulcers, so that the ulcer can be completely cured.