From the existing clinical data, there is no particularly obvious interaction between blood pressure-lowering drugs and hygromycin, but there is no clear data to support the joint use, so in order to ensure the safety of the drug, while taking blood pressure-lowering drugs need to be staggered with hygromycin. Antihypertensive drugs are a group of drugs aimed at lowering blood pressure, including calcium antagonists, diuretics, angiotensin transferase inhibitors, receptor blockers and so on, drugs in the process of use have different degrees of adverse reactions, including liver function, renal function damage, as well as dry cough, nausea, vomiting, double lower extremity edema and so on. Tetracycline antibiotic belongs to the tetracycline class, for a broad-spectrum bacteriostatic agent, the drug is more sensitive to Rickettsiae, Mycoplasma, Chlamydia, spirochetes, can be used for typhoid fever, paratyphoid fever, venereal disease, urethritis and so on caused by the above mentioned causative organisms. There are many adverse reactions to hyoscine, including hepatotoxicity, nephrotoxicity, gastrointestinal reactions, and neurological reactions. It needs to be contraindicated in people who are allergic to tetracyclines. Combination of oxytetracycline with acidulants, diuretics, and magnesium, iron, and calcium-containing drugs may interfere with the absorption of the drug. In order to ensure the safety of the drug, while taking antihypertensive drugs should be careful to stagger with hyoscine, and should be used under the guidance of a doctor.