How many injections of biologics for lupus erythematosus can not be determined, it varies from person to person. Biologics need to be applied for a long time, and with the alleviation of the condition, the dosage as well as the frequency of use can be gradually reduced. At present, the use of biologics for 6 months is more common in clinical practice, after which, as the patient’s condition eases, the dosage can be gradually reduced, the frequency can be reduced, and the treatment can eventually be changed to oral medication. Systemic lupus erythematosus (SLE) is an autoimmune disease with multi-system damage, and its diagnosis and treatment have some complexity. Clinically, biologics may be considered for the treatment of SLE patients who are ineffective, intolerant, or relapsing after hormonal and/or immunosuppressive therapy. Currently available biologics for the treatment of SLE include belimumab, which can significantly control disease activity, reduce hormone dosage, minimize organ damage, reduce the risk of severe relapse, and has a favorable safety profile. Clinically, Belimumab is used more often for 6 months, after which the dosage and frequency can be gradually reduced as the patient’s condition resolves, and eventually can be switched to oral medication. If SLE patients want to try biologics, it is recommended to go to the rheumatology and immunology department, and be evaluated by a professional doctor before using them. After using them, they should have regular follow-ups, and be evaluated by a professional doctor to assess the response to the biologics, and then work out the next cycle and frequency of treatment.