Trimethoprim maleate tablets can produce pain relief for some patients, but it is mainly through the regulation of gastrointestinal function to alleviate abdominal pain and other symptoms, not pain medication. Trimethoprim maleate tablets, the main component of which is trimethoprim maleate, can regulate gastrointestinal peristalsis, improve gastric emptying disorders, while the emptying, hypermotility plays an inhibitory role, which can effectively regulate gastrointestinal motility disorders. Through its regulation of gastrointestinal function, it can effectively regulate abdominal pain, loss of appetite, nausea and vomiting, abdominal distension, and abnormal defecation caused by gastrointestinal dysfunction, and can be used in the treatment of patients with irritable bowel syndrome. Therefore, for abdominal pain associated with gastrointestinal dysfunction, it can produce a certain degree of pain relief; however, it should be noted that the drug does not belong to painkillers. When abdominal pain occurs, it is recommended to go to the hospital in a timely manner, to clarify the cause of the pain, and to treat the cause; do not use drugs arbitrarily, not to mention blindly taking painkillers.