Sinusitis cefixime needs to be taken for 10-14 days. Sinusitis is clinically classified as acute or chronic based on whether the history is longer than 12 weeks. For acute sinusitis, clinical treatment guidelines recommend oral cephalexin of second generation or higher, or amoxicillin clavulanic acid potassium, commonly used as cefuroxime of second generation and cefixime of third generation, etc., based on bacterial culture of nasal secretions, and the course of treatment is usually 10-14 days. As for chronic sinusitis, clinical guidelines recommend that long term small doses of oral macrolide antibiotics above the fourteen dollar ring, commonly used are roxithromycin and clarithromycin, without the use of cephalosporin.