Whether one side of the goiter is important or not needs to be judged according to the degree of goiter and the nature of the goiter nodule, if it is malignant enlarged nodule, it is more serious. If the enlargement of one side of the thyroid gland is visible to the naked eye, it is mostly caused by thyroid nodules. It is recommended to do thyroid ultrasound to determine the nature of the nodule, whether it is cystic or solid, the blood flow of the nodule, whether it is accompanied by calcification, etc., to classify thyroid nodules, assess the benignity and malignancy of the nodule, and do a puncture pathology to clarify the benignity and malignancy, if necessary. If benign nodules have normal thyroid function, it does not matter, generally do not need to do special treatment, regular monitoring of thyroid function and review of thyroid ultrasound can be; if the thyroid function is abnormal, corresponding medication can be taken; if the nodule is malignant, or if the enlargement of the thyroid gland is serious, with symptoms of compression or affecting the aesthetics, surgical treatment can be performed. It is recommended to consult a doctor for timely treatment of enlarged thyroid.