This year, several outstanding young researchers have died prematurely due to diseases in China. If these diseases had been detected earlier and intervened in a timely and effective manner, would the outcome have been different? Of course, the complexity of diseases makes it difficult to diagnose many diseases at an early stage. Although physical examination is an effective means to diagnose diseases at an early stage, can brain tumor be detected at an early stage by regular body checkup? Whether brain tumor can be detected by physical examination depends on whether there are specific items for brain tumor in the physical examination program. Brain tumor will cause corresponding symptoms and signs when it grows to a certain size. The most common signs are the weakening of limb strength, uncoordinated movement, changes in vision, pupil, facial sensation, eye movement and tongue extension after cranial nerve injury, which can be detected through physical examination. However, when these signs appear, the tumor is likely to have grown larger and accompanied by other symptoms. Can brain tumor be detected by physical examination program before these signs appear? Many people think that they have taken many blood tests, can’t brain tumor be detected? The routine blood tests and biochemical tests in regular medical checkups are not specific for tumors, so they cannot detect tumors in general. There are some tumors have specific tumor markers, and tumors can be detected by blood sampling and checking these markers. However, brain tumors basically do not have specific tumor markers, so it is impossible to diagnose brain tumors through blood sampling. Even some special types of brain tumors such as pituitary tumor hormone test and germ cell tumor AFP and HCG need hematological results to assist in the diagnosis, it is necessary to combine with head imaging to complete the diagnosis. Of course, with the development of liquid biopsy technology in recent years, DNA fragments or other markers in blood or cerebrospinal fluid can be used to diagnose certain tumors, but there is still a long way to go before they can be used for screening brain tumors in physical examination. However, there is still a long way to go before brain tumor can be diagnosed by physical examination. However, from the perspective of screening brain tumors, a simple plain scan of MRI is sufficient, and if there is a tumor, it can usually be detected, and the radiation damage of CT examination is also avoided. If abnormal signals are indeed found in the brain, further enhancement scans and other serial scans of MRI can be done to further confirm. Therefore, it is difficult to detect brain tumor by regular physical examination, but it is possible to detect brain tumor at an early stage by targeted examination of brain.