Total cholesterol of 5.45 mmol/L and LDL of 3.53 mmol/L are mainly controlled by lifestyle improvement and medication. Generally speaking, the normal reference level of total cholesterol is less than 5.2mmol/L, and in the range of 5.2~6.2mmol/L belongs to the borderline level; the reference value of LDL is less than or equal to 3.4mmol/L, and in the range of 3.4~4.1mmol/L belongs to the borderline level. In summary, both indicators are borderline elevated. In this case, the first step is to improve the lifestyle, including avoiding oily and high-salt diet, maintaining appropriate intensity and frequency of aerobic exercise, and quitting smoking and drinking. If the effect of lifestyle improvement is still unsatisfactory, statins such as atorvastatin, ezetimibe, and colesevelam should be used under the guidance of a doctor to assist in lipid lowering. In summary, it is recommended to consult a doctor to receive standardized diagnosis and treatment when necessary.