There are many reasons for coughing and deep breathing chest pain, which is common in pneumonia, acute trachea-bronchitis, tuberculosis pleurisy, etc. Treatment should be based on the specific cause, and anti-inflammatory, expectorant, bronchodilator, anti-tuberculosis treatment can be given. 1. Pneumonia: prolonged coughing can lead to retrosternal pain and chest pain, but it rarely manifests as pleurisy-like pain. Sensitive antimicrobial drugs, such as penicillin, cefprozil dispersible tablets, cefixime granules, etc., can be given according to the results of sputum culture and drug sensitivity test. 2. Acute trachea-bronchitis: when the inflammation involves the trachea, cough, sputum, often irritating dry cough, a small amount of mucus sputum with retrosternal discomfort or dull pain. Bronchodilators such as ambroxol expectorant, salbutamol sulfate inhalation aerosol, erythromycin or clarithromycin anti-inflammatory can be given. 3. Tuberculous pleurisy: some patients have typical early symptoms, such as mild fever, cough and chest pain. Isoniazid, streptomycin and other drugs can be given. Cough with chest pain may also have other causes, it is recommended to go to the hospital in a timely manner, improve the examination to clarify the cause of the disease, give targeted treatment or treatment. The above drugs should be used under the guidance of a doctor, avoid self-medication.