Exercise itchy body is considered to be cholinergic urticaria. The cause of cholinergic urticaria is mostly related to exercise, drinking alcohol, eating hot drinks, etc. Therefore, after exercise, itching all over the body, clinically considered to be cholinergic urticaria, due to the body’s blood circulation accelerated, body temperature rises, so that the cholinergic nerve impulse to release acetylcholine, which acts on the mast cells, thus causing urticaria manifestations. Patients with cholinergic urticaria mainly manifested as windy masses with intense itching. Patients can follow the doctor’s instructions oral antihistamines, such as loratadine, fexofenadine, etc., to promote recovery. For patients who exercise all over the body itching, it is recommended to go to the regular hospital dermatology consultation, clear diagnosis.