Amiodarone and dronedarone can be used interchangeably. Amiodarone and dronedarone are class III antiarrhythmic drugs, both can be used in patients with atrial fibrillation to maintain sinus rhythm treatment, the two drugs can be used interchangeably in clinical practice, depending on which drug the patient is suitable for. Amiodarone adverse reactions chills, indifference, fatigue, dry cough, dyspnea, corneal deposits, etc., severe hypotension, sick sinus node syndrome without pacemaker protection, allergic to the drug components, pregnant women, children patients are prohibited. Adverse reactions to dronedarone are nausea, vomiting, abdominal pain, diarrhea, hypersensitivity to the components of the drug, permanent atrial fibrillation, patients taking drugs that may cause prolongation of the QT interval, severe hepatic impairment, pregnant patients are contraindicated. When amiodarone and dronedarone are used interchangeably, it is important to use the drug under the supervision of a physician and pay attention to the adverse effects of the drug.