Colonic plasma membrane surface roughness refers to the loss of smoothness of the plasma membrane surface of the colon and the emergence of localized elevation or surface damage, thus becoming rough, generally need to consider colitis or cancer. 1. Colitis: Inflammation of the colon is the most probable cause of colon plasma membrane roughness. When the local mucosal surface of colon is damaged or ulcerated, it will cause roughness of the plasma membrane surface, which will lead to different degrees of abdominal pain, gastrointestinal bleeding, diarrhea and other discomforts, and need to take antibiotics such as norfloxacin or anti-inflammatory drugs such as mesalazine in time for treatment. 2. Cancer: when there is early cancer or malignant tumor proliferation on the surface of local colon, it will also lead to roughness on the plasma membrane surface, which can be considered as irregular elevation on the surface of colon caused by local hyperplasia, and it needs to be resected as soon as possible to avoid proliferation and spread of cancer cells. At the same time, for malignant tumors caused by plasma membrane roughness also need to be reviewed regularly after treatment. After the discovery of plasma surface roughness, it is recommended to go to the hospital for endoscopy in time and cooperate with the doctor to choose the appropriate medication to treat it carefully.