There are many reasons for walking calf pain, such as calf muscle strain, lactic acid accumulation, lower limb vascular disease, lumbar spine disease, etc. To relieve it quickly, we need to address the cause of the disease and give general treatment, physical therapy, medication, and surgery and other comprehensive treatment. 1. Muscle strain: Walking more, especially when walking fast, can easily lead to calf muscle strain, you can take ibuprofen and other painkillers to treat the acute stage to give local cold compresses, while the relief period can be given to the local hot compresses, which will help relieve the symptoms. 2. Lactic acid accumulation: when walking more, the calf muscle lactic acid accumulation, the patient can appear calf pain, you can massage the calf muscle, hot compresses, pain is obvious can also be given to non-steroidal anti-inflammatory drugs such as diclofenac sodium treatment. 3. Lower extremity vascular disease: the more common varicose veins of the saphenous vein, calf pain. For mild cases, compression stockings can be worn, and for serious cases, high ligation of saphenous vein + stripping operation can be carried out. 4. Lumbar spine diseases: the more common ones are lumbar disc herniation, spinal stenosis, etc. The compression of nerve root can cause radiating pain on the outer side of the calf, which can be treated with painkillers such as ibuprofen and nutritive drugs such as methylcobalamin and physical therapies such as hot compresses, and in serious cases, surgical treatments such as radiofrequency ablation can be given. It is recommended that patients go to the hospital to improve the examination to clarify the condition, the drug has different side effects and contraindications, so need to be used under the guidance of a professional physician.