The pain of advanced bone metastasis of prostate cancer is caused by the metastasis of cancer cells to the bone tissue, which causes some damage to the bones. Prostate cancer is a malignant tumor that occurs in the epithelium of the prostate gland, which belongs to the common malignant tumors of male genitourinary system. Its etiology is related to heredity, genetic changes, improper diet, obesity and other factors. Generally, patients with prostate cancer have no obvious symptoms in the early stage, and with the growth of the tumor, symptoms of lower urinary tract obstruction such as urinary frequency, urinary urgency and urination difficulty may appear. With the development of the disease, in the advanced stage of prostate cancer, some patients may have bone metastasis. When the cancer cells metastasize to the bone tissues, they can press the bone tissues and cause certain damages to them, resulting in bone pain, swelling and numbness of lower limbs, accompanied by weight loss, fatigue, loss of appetite, etc. Once the prostate cancer patients develop bone metastasis, they may suffer from bone pain and numbness. Once prostate cancer patients develop bone metastasis, they need to actively report to the doctor and take relevant treatment measures in cooperation with the doctor, so as to avoid delaying the condition.