Chewing betel nut with white pain in the mouth may be oral leukoplakia, the treatment includes removing irritating factors, medication, physical therapy, etc., as follows. 1. Remove the stimulating factors: stop chewing betel nut, quit smoking, and reduce the consumption of acidic, spicy, hot and other stimulating foods. 2. Medications: such as retinoic acid, which can affect the metabolism of epithelium, has the effect of promoting the proliferation and differentiation of epithelial cells and keratolysis, and can prevent epithelial hyperkeratosis, which is suitable for oral leukoplakia with high degree of keratinization. Drugs should be used under the guidance of a doctor. 3. Physical therapy: including photodynamic therapy, laser therapy, cryotherapy, etc., which can effectively get rid of the lesions with little trauma and less bleeding. It is recommended to go to the hospital in time for early targeted treatment. At the same time in the treatment should no longer eat betel nut.