Mild atypical hyperplasia of esophageal mucosa can be relieved by general treatment, medication such as omeprazole, bismuth potassium citrate, mosapride, and surgery. 1. General treatment: patients should pay attention to diet, avoid eating too cold, too spicy, too hot and other stimulating food to the esophageal mucosa, less strong tea, strong coffee, etc., and eat more fresh fruits and vegetables and other light, easy-to-digest food. At the same time, ensure enough rest, avoid staying up late, and strengthen the exercise properly to enhance the physical fitness of oneself. 2. Drug treatment: mild atypical hyperplasia of esophageal mucosa is mostly considered to be caused by gastric acid reflux. Acid inhibiting drugs such as omeprazole can be taken to reduce the secretion of gastric acid; mucosal protection drugs such as bismuth potassium citrate can be taken to alleviate the damage of the esophageal mucosa; and pro-dynamic drugs such as mosapride can be taken to promote the evacuation of gastric acid and food from the stomach and alleviate the reflux. 3. Surgical treatment: patients with mild atypical hyperplasia of esophageal mucosa should have regular rechecks, and if the disease is found to develop further or have a tendency to become cancerous, endoscopic treatment or surgical treatment can be considered. Mild atypical hyperplasia of esophageal mucosa is a kind of pre-cancerous lesion, which may become cancerous, so it is recommended that patients should consult doctor in time and accept treatment actively, and take medicines strictly according to the doctor’s prescription, and should not take medicines by themselves, so as to avoid delaying or even aggravating the condition.