Stage III syphilis belongs to the late syphilis, from the onset of the site can be divided into: skin and mucous membrane damage, bone syphilis, cardiovascular syphilis, neurosyphilis and so on, the specific symptoms are as follows: 1. Skin and mucous membrane damage: it may cause head and face, shoulder, extension of the limbs, the emergence of nodular syphilis rash, resulting in localized copper-red infiltration nodules, surface desquamation, necrosis, ulceration. There may also be syphilitic tumors, also known as syphilitic trephines, can occur in the face, lower limbs and other parts of the skin damage is painless, ulcerated nodules, kidney-shaped or horseshoe-shaped, clear boundaries, ulcerated surface there will be mucous trephine-like secretion. 2. Bone syphilis: the most common parts are skull, tibia and other parts, which will cause bone pain, pathologic fracture, osteoarthritis, joint deformity and so on. 3. Cardiovascular syphilis: it may lead to syphilitic simple aortitis, syphilitic aortic valve insufficiency, syphilitic aortic aneurysm, etc. The patients may be asymptomatic, or they may have symptoms similar to angina pectoris, which is usually life-threatening. 4. Neurosyphilis: including syphilitic meningitis or cerebral parenchymal syphilis, etc. Patients usually show symptoms such as headache, mental behavioral abnormalities, cognitive decline, hemiplegia, epilepsy and so on. It is recommended that patients with syphilis go to regular hospitals for timely examination and standardized treatment in accordance with medical advice.