The treatment of corpus callosum infarction is similar to other cerebral infarction, mainly including general treatment, specific treatment, comorbidities treatment, rehabilitation treatment and so on. 1. General treatment: give oxygen when necessary, pay attention to the monitoring of vital signs, pay attention to the control of blood pressure and blood glucose and other treatments. 2. Specific treatment: intravenous thrombolysis such as alteplase, arterial thrombolysis and other endovascular interventions, antiplatelet therapy such as aspirin, and cerebral protection therapy such as edaravone can be appropriately applied according to the condition. 3. Treatment of comorbidities: Mannitol can be applied appropriately in cases of combined cerebral edema; post-infarction hemorrhage should stop using hemorrhage-causing drugs; antibiotics such as cefotaxime can be selected according to drug sensitivity test in cases of concomitant infections. 4. Rehabilitation therapy: For patients with stable condition, rehabilitation therapy should be carried out as early as possible, such as limb movement in bed, bedside activities, etc., which can be supplemented with acupuncture and physiotherapy. The symptoms of cerebral infarction should be diagnosed and treated in time, and all treatments and medications should be administered according to the doctor’s instructions.