Difficulty in sleeping at night with fever in the hands and feet may be caused by autonomic dysfunction, hyperthyroidism, sleep environment, etc. It can be relieved by glutamine tablets, methimazole tablets, and improvement of sleep environment. However, if the fever is more than 38.5 degrees Celsius, it is necessary to reduce the fever through antipyretic drugs, such as ibuprofen, acetaminophen and so on. 1. Autonomic dysfunction: Due to the decrease of estrogen level in the body, it will cause autonomic dysfunction, which will lead to hot hands and feet at night, difficulty in falling asleep, irritability and so on. It can be improved by taking oral glutamine tablets, vitamin B1 tablets and other drugs, the specific medication should follow the doctor’s instructions. 2. Hyperthyroidism: patients with hyperthyroidism, due to their own body’s thyroid hormone more, improve their own tissue metabolism, prone to emotional excitement, hyperactivity and so on, resulting in people sleeping with hot hands and feet, sleep difficulties and other symptoms. Under the guidance of the doctor can be relieved by methimazole tablets and other drugs. 3. Sleep environment: when sleeping at night, if the temperature is too high, too much light, etc., may lead to sympathetic nerve excitation, fever, irritability, difficulty in sleeping, etc., need to improve the sleep environment to alleviate the symptoms. If necessary, under the guidance of the doctor can also be improved by lorazepam tablets and other drugs. Patients who have difficulty sleeping at night with hot hands and feet should seek medical treatment in time to avoid adverse reactions.