Lupus erythematosus usually refers to systemic lupus erythematosus, and its life expectancy cannot be generalized. Generally speaking, after active standardized and effective treatment, the survival period of most patients with stable disease control can be more than 10 years. If the internal organs are damaged, the condition is serious, and the condition is not well controlled, it is difficult to survive for 10 years. The life expectancy of SLE is generally related to the severity of the disease, the specific type of disease, the effectiveness of treatment and the individual’s condition, and cannot be generalized. After active standardized and effective treatment, most of the patients with stabilized disease control can survive for more than 10 years. If the internal organs are damaged, the condition is serious, and the condition is not well controlled, it is difficult to survive for 10 years. Therefore, early detection, early diagnosis and early treatment are particularly important. The main causes of death in acute phase SLE patients are severe damage to multiple organs and infections, especially those with severe neuropsychiatric lupus, pulmonary hypertension and acute progressive lupus nephritis; chronic renal insufficiency and adverse reactions to medications, coronary atherosclerotic heart disease, etc., which are the main causes of their long-term deaths. Although SLE cannot be completely cured at present, the survival time of patients can be significantly improved after standardized diagnosis and treatment, so it is recommended that patients should actively cooperate with their doctors in order to actively control the disease.