Connective tissue diseases can be treated by medication and surgery. Connective tissue diseases mainly include systemic lupus erythematosus, rheumatoid arthritis, systemic sclerosis, polymyositis and so on. 1. Systemic lupus erythematosus: (1) Glucocorticoid: commonly used such as prednisone, prednisolone, hydrocortisone and so on; (2) change the condition of anti-rheumatic drugs: commonly used cyclophosphamide, azathioprine, cyclosporine, ralph lauren, hydroxychloroquine and so on. 2. Rheumatoid arthritis: (1) Surgical treatment: finger rheumatoid arthritis late lesions are static, joints have obvious deformity cases feasible arthroplasty, joint ankylosis or destruction can be arthroplasty, artificial joint replacement. Weight-bearing joints can be joint fusion. (2) Drug therapy: drugs for rheumatoid arthritis include non-steroidal anti-inflammatory drugs such as diclofenac, immunosuppressive drugs such as methotrexate, leflunomide and glucocorticosteroids such as prednisone. 3. Systemic sclerosis: Drug therapy with calcium channel blockers such as nifedipine and diltiazem. Glucocorticoids such as prednisone. Immunosuppressants such as cyclosporine, cyclophosphamide, azathioprine and so on. 4. Polymyositis: Glucocorticosteroids such as dexamethasone, prednisolone, hydrocortisone, etc. are usually used. Immunosuppressants such as methotrexate, cyclophosphamide and other drugs. Combined immunoglobulin therapy may also be used in the acute phase. Patients with connective tissue disease are advised to seek timely medical attention.