Creatinine 160μmol / L if belongs to the physiological increase, generally not serious, will not enter the uremia; if belongs to the pathologic increase in acute kidney injury caused by the elevation, generally not serious, usually will not enter the uremia, if the chronic increase, it is more serious, will gradually enter the uremia, the specific time can not be generalized, ranging from a few years. 1. Physiological elevation: generally not serious, and do not need special treatment. For example, after strenuous exercise, eating a lot of meat food, too much emotional stress and anxiety, etc., may lead to high creatinine, but physiological factors caused by high creatinine will not affect renal function and renal excretion, so it is not serious, but it is still recommended to review regularly to assess renal function. 2. Pathological increase (1) If creatinine 160μmol/L is pathologically elevated, the excretion of renal function has been changed. If the increase is acute, such as diarrhea, infection and other transient increase in creatinine, after removing the cause of the disease and symptomatic treatment, it can usually be recovered, so it is not serious. (2) If the elevated creatinine is chronic, i.e. chronic renal failure, it will be more serious, if not treated in time, the condition will be further aggravated and develop into uremia, the specific time varies from several years. If the creatinine is found to be elevated, it is recommended that patients go to the hospital in time for examination, to clarify the cause of the disease, and actively treat under the guidance of the doctor.