No acid reflux and no heartburn, but also may be gastroesophageal reflux. Typical symptoms of gastroesophageal reflux are acid reflux, heartburn with retrosternal pain. However, some patients are not sensitive to gastric acid, so when gastric fluid flows back into the esophagus, it will not show obvious acid reflux, heartburn and other discomforts, but it may be accompanied by retrosternal pain, and at this time, it is necessary to clarify whether it is gastroesophageal reflux through gastroscopy. Therefore, it is possible to have GERD without acid reflux or heartburn. The diagnosis of GERD needs to be confirmed by the combination of symptoms and gastroscopy. When the patient is not feeling well, the diagnosis must be made by combining the specific symptoms and the corresponding test results, and the diagnosis should not be based on the symptoms of no acid reflux and no heartburn alone. If the above symptoms occur, it is recommended to go to the hospital in time for early and regular treatment.