Patients with gallbladder interstitial stones need to be observed and treated surgically according to the size and number of stones. 1. For patients with single gallbladder stones with a diameter of less than 3 centimeters, regular review of abdominal ultrasound or abdominal CT will be sufficient to observe the changes in the diameter of the gallbladder stones, and they should drink plenty of fluids and exercise appropriately. 2. For multiple gallbladder stones, no matter how big the gallbladder stones are, it is advocated to have the gallbladder surgically removed for treatment, this is because gallbladder stones repeatedly act on the gallbladder, which will induce the risk of cancerous changes and gallbladder cancer. 3. For gallbladder stones larger than 3 centimeters in diameter, it is recommended that patients undergo gallbladder stone removal surgery, also due to the risk of cancer. Therefore, patients with gallbladder stones should go to the hospital in time if they have any discomfort, and should not be careless so as not to miss the best time for treatment.