If there is no Helicobacter pylori infection, the main thing is to take acid suppressant and gastric mucosa protector, if there is Helicobacter pylori infection, it needs to take quadruple therapy. Intestinal chemosis is usually caused by chronic atrophic gastritis, mainly to inhibit the secretion of gastric acid and promote mucosal repair, can take omeprazole, rabeprazole, bismuth potassium citrate, aluminum thioglycollate and so on. If Helicobacter pylori infection exists, systematic quadruple therapy is needed, i.e. one proton pump inhibitor, one bismuth agent and two antibiotic drugs, such as omeprazole, bismuth pectin, amoxicillin and metronidazole. Intestinal chemosis should be timely to the hospital, with the doctor’s medication treatment, not self-medication.