The fruits that should not be eaten when taking targeted drugs include Israeli green grapefruit, grapefruit and Seville oranges.
Israel green grapefruit, grapefruit and Seville oranges and other fruits contain high levels of furanocoumarins and their compounds have a strong inhibitory effect on the activity of CYP3A4, which can interfere with the metabolism of antitumor drugs, thus having a certain impact on the therapeutic effect.CYP3A4 is an important enzyme to help the human body break down and absorb the targeted drugs.
Some fruits contain furanocoumarins, naringin and flavonoids that inhibit the activity of the CYP3A4 enzyme in the liver and intestinal system, resulting in the body’s metabolism of the drug slowing down or even stopping. The concentration of the drug in the blood increases exponentially, thus causing the incidence of adverse reactions to increase exponentially.
Fruits containing furanocoumarins include Israeli green grapefruit, grapefruit, Seville orange, shaddock, red grapefruit, pomegranate, poppyseed, etc. Therefore, these fruits should not be eaten during the period of taking targeted drugs.
In addition, try to avoid eating spicy and stimulating, fried, smoked and barbecued food during the period of taking targeted drugs, and try to quit smoking and drinking.