Creatinine 220μmol/L may be caused by renal insufficiency, if not accompanied by elevated uric acid is not recommended to take febuxostat, accompanied by elevated uric acid can take febuxostat.
Creatinine is the metabolic end product of creatine in muscle tissue. Creatinine is not combined with protein in the blood, and can freely pass through the glomerulus, which is currently the most commonly used indirectly reflect the glomerular filtration function of the indicators.
Normal serum creatinine ranges from 53 to 106 μmol/L in men and from 44 to 97 μmol/L in women, and creatinine 220 μmol/L usually indicates the presence of renal insufficiency.
Febuxostat is a drug that inhibits uric acid synthesis and is indicated for patients with gout and hyperuricemia; no dose adjustment is needed for patients with mild to moderate renal insufficiency. Therefore, patients with creatinine 220 μmol/L with hyperuricemia can take Febuxostat.
Febuxostat can cause adverse reactions such as weakness, edema, fatigue, mood abnormalities, gait disturbance, pain, and thirst. It is contraindicated in patients who are being treated with azathioprine and mercaptopurine.
If the patient has an elevated creatinine, it is recommended to go to the regular hospital in time, under the guidance of the doctor to use the drug, avoid self-medication to avoid adverse effects.