When taking statins, it is recommended to eat fewer grapefruits, tangerines, oranges, and to be careful not to take them at the same time as much as possible. Statins are currently the most effective lipid-lowering drugs, not only can strongly reduce total cholesterol (TC) and low-density lipoprotein (LDL) levels, but also can reduce triglycerides (TG) to a certain extent, and elevate the level of high-density lipoprotein (HDL), so statins can also be called a more comprehensive lipid-regulating drugs. Such drugs have adverse reactions such as liver and kidney function damage, pomelo, tangerines, oranges and other citrus fruits have furan coumarin, this substance will inhibit the activity of the CYP3A4 enzyme, and some statin drugs need to be metabolized by the CYP3A4 enzyme, if excessive consumption of such fruits, may affect the metabolism of the drug, increase or aggravate the incidence of adverse reactions to the drug. Therefore, patients taking statin drugs, please pay attention to consult the doctor when applying Chinese medicine treatment, so as not to increase the risk of adverse reactions.