Mycoplasma weakly positive, infusion for five days, coughing at night, can be treated with azithromycin for anti-mycoplasma treatment, but also symptomatic treatment, the use of aminobromine hydrochloride and other drugs to relieve coughing symptoms. 1. Causal treatment: after five days of infusion is still coughing at night, it is likely that the mycoplasma is not completely controlled, should continue to use azithromycin, erythromycin and other drugs infusion treatment. It should be noted that mycoplasma weak positive is not a pointer to infusion, for light patients can generally be given orally, for serious symptoms, combined with other infections or the elderly frail patients with poor physical condition can infusion treatment. It is also possible that the patient is not sensitive to the current drug, through the bacterial culture and drug sensitivity test to select sensitive antibiotics for treatment. 2. Symptomatic treatment: Mycoplasma infection can cause cough, if the cough symptoms are not relieved, you can use aminobromine hydrochloride and other cough suppressants for relief. Mycoplasma weak positive infusion of five days at night coughing, there may be other reasons, such as patients with bacterial infections, the need to use amoxicillin, cefuroxime and other anti-infective treatment, may also be accompanied by other diseases, such as cough variant asthma, can be given to montelukast sodium antiallergic treatment. All of the above drugs need to be used under the guidance of a physician to avoid self-medication. It is recommended that patients with discomfort communicate with the physician in charge in a timely manner, and if necessary, adjust the medication program.