Pain on both sides of the waist is most commonly seen in lumbar spine lesions such as lumbar disc herniation, lumbar muscle strain, urinary system diseases, reproductive system diseases and ankylosing spondylitis, etc., which need to be perfected in order to clarify the cause of the disease. 1. Lumbar spine lesions: the more common ones are lumbar intervertebral disc herniation, osteophytes, lumbar spinal stenosis and lumbar spine tumors, etc. The lesions cause pressure on the nerves in the lumbar region, which can lead to pain on both sides of the waist. 2. Lumbar muscle strain: mostly seen in long-term weight bearing, improper posture, strenuous exercise, etc., belonging to the chronic injury of lumbar muscles, if both sides of the lumbar muscles are strained, there will be pain on both sides of the waist. 3. Urological diseases: more common are nephritis, kidney stones, etc., which can lead to pain on both sides of the waist, lumbar pain is mostly in the upper lumbar region, and is often accompanied by hematuria and other changes in the urinary system. 4. Reproductive system diseases: mostly seen in female patients, common female pelvic inflammatory disease, adnexitis, ovarian cysts, etc., can cause pain on both sides of the waist. 5. Ankylosing spondylitis: it is a chronic autoimmune disease that affects the spine and can cause pain on both sides of the waist, mostly accompanied by morning stiffness. It is recommended that patients seek medical examination in time to clarify the cause of the disease, and professional physicians will give appropriate treatment for the cause of the disease.