Methylprednisolone and prednisone acetate both belong to the glucocorticoid class of drugs, and in terms of efficacy, they are actually almost the same. However, there are differences in their metabolic pathways, indications and preparation forms. 1. Metabolic characteristics: methylprednisolone does not need to be metabolized by the liver after taking, can be directly effective, while prednisone acetate needs to be metabolized by the liver to play a role. 2. Indications: Methylprednisolone is preferred in patients with severe liver disease. Methylprednisolone injection is preferred for patients with severe and acute renal disease who need intravenous hormone injection. 3. Formulation form: methylprednisolone is more water-soluble, generally for the injection preparation, while prednisone acetate is poorly water-soluble, generally for oral preparation. 4. Price difference: Prednisone acetate is relatively less expensive than methylprednisolone. The above drugs should be used in accordance with medical advice, do not use without authorization, so as not to cause adverse consequences.