The difference between Zuo Gui Wan and Zhi Bai Di Huang Wan lies in the differences in drug composition and main treatment. Composition: Zuo Gui Wan consists of Radix Rehmanniae Praeparata, Semen Cuscutae, Radix Achyranthis Bidentatae, Radix et Rhizoma Gastrodiae, Radix Angelicae Sinensis, Cornu Cervi Pantotrichum and Fructus Lycii. Zhi Bai Di Huang Wan is composed of Zhi Mu, Huang Bai, Radix Rehmanniae Praeparata, Cornu Cervi Pantotrichum, Mudan Pi, Rhizoma Coptidis, Poria, and Zedoaria. Indications: Zuo Gui Wan is used for lumbar soreness and knee weakness caused by true yin deficiency, night sweating (abnormal sweating after going to sleep and stopping sweating after waking up), mental fatigue (lack of mental energy) and dry mouth. Zhi Bai Di Huang Wan is used for hot flashes (a burst of fever) and night sweating caused by yin deficiency (deficiency of yin and essence in the body and hyperactive fire), dry mouth and sore throat, tinnitus and spermatorrhea, and short and red urination (small amount of urination and dark yellow color). It is contraindicated for pregnant women, and Zuo Gui Wan is contraindicated for children. If you need to use the drug, should be used under the guidance of a doctor, do not blindly self-medication.