Demyelinating changes in the brain can be caused by immune disorders, chronic ischemia and genetic factors. Immune dysfunction: patients with immune dysfunction, abnormal immune cells or abnormal antibodies in the body, resulting in immune inflammatory reaction, leading to cerebral demyelination lesions. Chronic cerebral ischemia: If the patient has high blood pressure or diabetes mellitus, which leads to cerebral small blood vessel lesions and chronic cerebral hypoperfusion, then demyelination changes may occur. Genetic factors: Diseases in which myelin formation is defective due to genetic factors and normal development cannot be accomplished, representative diseases include heterotrophic cerebral leukodystrophy, adrenoleukodystrophy, and so on. When patients find brain demyelination changes, they should consult the doctor in time, complete the relevant examination and regular treatment.