Due to the differences in patients’ conditions and physical conditions, there is no such thing as which one is better, Methylcobalamin or Epalrestat tablets, and which one is good for the patient’s suitability for which medicine. The dosage forms of methylcobalamin include tablets, capsules and injections, which are used in the treatment of peripheral neuropathy. Adverse reactions such as loss of appetite, nausea, vomiting, diarrhea, and rash can occur after using this product, and the medication is stopped when it occurs. Epalrestat tablets are indicated for diabetic neuropathy, and adverse reactions such as erythema, blisters, rash, pruritus, increased aspartate aminotransferase, increased alanine aminotransferase, diarrhea, nausea, vomiting, abdominal pain, dizziness, and drowsiness may occur after use of this product. Methylcobalamin is contraindicated in pregnant and lactating women, and in patients with a history of hypersensitivity to the product. Patients who want to use methylcobalamin and Epalrestat tablets are advised to go to regular hospitals, consult professional doctors, cooperate with doctors to complete the relevant examinations, and avoid blind use of drugs.