High thyroglobulin antibodies need to pay attention to check the thyroid function, and at the same time should pay attention to ultrasound examination to determine whether the thyroid morphology is abnormal, to check whether there is a combination of other autoimmune diseases, and recommend timely medical treatment. Elevated anti-thyroglobulin antibodies suggest the presence of autoimmune thyroid disease, which is the main cause of hypothyroidism in adults, so it is necessary to check the thyroid function to determine whether there is hypothyroidism. Antithyroglobulin antibodies are elevated, and an ultrasound of the thyroid gland is needed to understand the morphology of the thyroid gland and to rule out other thyroid disorders. If there are other autoimmune symptoms such as dry mouth and dry eyes, autoimmune diseases such as dry syndrome should also be investigated. Therefore, high thyroglobulin antibodies require further evaluation of thyroid function, thyroid ultrasound, and the presence of other autoimmune diseases, and endocrinology consultation is recommended.